Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche ''Togo Rosati''

Authors    Pagano C, Perioli L, Baiocchi C, Bartoccini A, Beccari T, Blasi F, Calarco P, Ceccarini M R, Cossignani L, di Michele A, Ortenzi R, Scuota S, Ricci M

Abstract   The aim of this study was to develop an innovative formulation, particularly useful for the treatment of exuding wounds. An extract from Moringa oleifera leaves (MOE), prepared by an eco-friendly method, was used as active ingredient. Its preliminary characterization showed that MOE is rich in quercetin-O-glucoside and quercetin-O-malonyl glucoside, responsible for the antioxidant, radical scavenging and antibacterial activities (toward Staphylococcus aureus, S. epidermidis, S. faecalis and S. pyogenes). Moreover, MOE showed the ability to stimulate keratinocytes growth. Thus, bioadhesive biocompatible polymeric microparticles loaded with such extract were developed and prepared in order to treat exuding wounds. The microparticles, obtained by spray drying, using chitosan as polymer, showed good swelling ability. This is useful to obtain the transition from microparticles to a continuous gel covering the wound, after deposition on it. This has the double function to protect the damage area and to promote the healing. The in vitro release study showed that the formed gel is able to release immediately MOE, in the first minutes after application, and to promote a sustained release within 24 h reaching an efficacious concentration against the most sensitive bacterial strains. These findings suggest that the developed microparticles represent an interesting tool for exuding wounds treatment.

Publish Date  2020

Volume    587

ISSN        1873-3476

DOI          doi.org/10.1016/j.ijpharm.2020.119700

URL          https://www.sciencedirect.com/science/article/pii/S0378517320306840?via%3Dihub

Journal    International Journal of Pharmaceutics

Pages      art. n. 119700

PMID       32738457