Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche ''Togo Rosati''

Authors    Pagano C, Marinozzi M, Baiocchi C, Beccari T, Calarco P, Ceccarini M R, Chielli M, Orabona C, Orecchini E, Ortenzi R, Ricci M, Scuota S, Tiralti M C, Perioli L

Abstract   The onion non-edible outside layers represent a widely available waste material deriving from its processing and consumption. As onion is a vegetable showing many beneficial properties for human health, a study aiming to evaluate the use of extract deriving from the non-edible outside layers was planned. An eco-friendly extraction method was optimized using a hydroalcoholic solution as solvent. The obtained extract was deeply characterized by in vitro methods and then formulated in autoadhesive, biocompatible and pain-free hydrogel polymeric films. The extract, very soluble in water, showed antioxidant, radical scavenging, antibacterial and anti-inflammatory activities, suggesting a potential dermal application for wounds treatment. In vitro studies showed a sustained release of the extract from the hydrogel polymeric film suitable to reach concentrations necessary for both antibacterial and anti-inflammatory activities. Test performed on human keratinocytes showed that the formulation is safe suggesting that the projected formulation could be a valuable tool for wound treatment.

Publish Date  2020

Volume    25 (2)

ISSN        1420-3049

DOI          doi.org/10.3390/molecules25020318

URL          https://www.mdpi.com/1420-3049/25/2/318

Journal    Molecules

Pages      art. n. 318

PMID       31941100