Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche ''Togo Rosati''

Authors  Crotti S, Cruciani D, Sabbatucci M, Spina S, Piscioneri V, Torricelli M, Calcaterra R, Farina C, Pisano L, Papini M

Abstract Background: In recent decades, globalization and international migration have increased the spread of infectious agents, including dermatophytes. Although considered minor infections, dermatophytoses are highly contagious, and they significantly reduce the quality of life, inducing itching, burning, sleep disturbances, and even depressive states. Moreover, the increasing resistance to antifungals threats the public health and burdens the costs for the healthcare system. Methods: DermaGenius® Resistance Multiplex real-time PCR assay allowed to analyze the terbinafine susceptibility/resistance of 172 Trichophyton strains, which were isolated from human and animal samples collected from 2016 to May 2024 and previously identified by Sanger sequencing. Results: All the 11 animal strains belonged to the T. interdigitale / T. mentagrophytes complex and tested terbinafine sensitive. Out of 161 human strains, 9 (5,6%) showed terbinafine resistance and 7 (4,3%) were identified as T. indotineae. Conclusions: This study provides preliminary data about behavior toward antifungals in animals and finalizes the scientific information currently available about human strains, highlighting the importance of the One Health concept. Moreover, it supports the relevant role of T. indotineae as an emerging dermatophyte with high proportion of terbinafine resistance.

Publish Date 2024

Volume 13 (18)

ISSN 2077-0383

DOI doi.org/10.3390/jcm13185493

URL https://www.mdpi.com/2077-0383/13/18/5493

Journal  Journal of Clinical Medicine

Pages art. no. 5493

PMID 39336980